Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

DOI: 10.1021/jm00360a013

Source and publish data:

Journal of Medicinal Chemistry p. 855 - 861 (1983)

Update date:2022-08-04

Topics:

Authors:

Clark Clark

Caroon Caroon

Repke Repke

Strosberg

Bitter Bitter

Okada Okada

Michel Michel

Whiting Whiting

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Article abstract of DOI:10.1021/jm00360a013

Forty-one 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones were prepared for antihypertensive screening in the spontaneously hypertensive rat (SHR). For the 9-(2-indol-3-ylethyl) series, the parent compound 9-(2-indol-3-ylethyl)-1-oxa-4,9-diazaspiro[

Full text of DOI:10.1021/jm00360a013

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