
Journal of Heterocyclic Chemistry p. 1459 - 1461 (1997)
Update date:2022-07-29
Topics:
Perandones, Francisco
Soto, Jose L.
Reactions of 4-amino-1,2-dimelhylimidazole-5-carbaldehyde (1) and 5-amino-1-methylimidazole-4-carbaldehydes 3 with nitriles, in the presence of dry hydrogen chloride afforded to the formation of purine derivatives. This constitutes a facile and versatile one-pot synthesis of purines. The use of formamide instead of nitriles leads to the respective purines without substituents on the pyrimidine ring, 2d and 4e,f.
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