An Expeditious Procedure for the Synthesis of Purines from Aminoimidazolecarbaldehydes

Article abstract of DOI:10.1002/jhet.5570340514

Reactions of 4-amino-1,2-dimelhylimidazole-5-carbaldehyde (1) and 5-amino-1-methylimidazole-4-carbaldehydes 3 with nitriles, in the presence of dry hydrogen chloride afforded to the formation of purine derivatives. This constitutes a facile and versatile one-pot synthesis of purines. The use of formamide instead of nitriles leads to the respective purines without substituents on the pyrimidine ring, 2d and 4e,f.