Synlett p. 1281 - 1283 (2001)
Update date:2022-09-26
Topics:
Gautheron-Chapoulaud
Pandya
Cividino
Masson
Py
Valle?e
The zinc-mediated reduction of nitroalkanes and nitroarenes in the presence of aldehydes is an efficient method to synthesize a wide range of nitrones. This method is mild enough to accommodate a variety of functional groups. It is particularly useful when the intermediate hydroxylamines are unstable and/or water-soluble. We used it to prepare several aromatic, aliphatic and highly functionalized sugar-derived nitrones.
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