Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3- carboxylic acid

DOI: 10.1021/jo050178+

Source and publish data:

Journal of Organic Chemistry p. 3592 - 3601 (2005)

Update date:2022-08-05

Topics:

Authors:

Chung, John Y. L.

Cvetovich, Raymond

Amato, Joseph

McWilliams, J. Christopher

Reamer, Robert

DiMichele, Lisa

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Article abstract of DOI:10.1021/jo050178+

(Chemical Equation Presented) A practical asymmetric synthesis of N-tert-butyl disubstituted pyrrolidines via a nitrile anion cyclization strategy is described. The five-step chromatography-free synthesis of (3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrr

Full text of DOI:10.1021/jo050178+

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