Reduction of 1,3-Diimines. A New and General Method of Synthesis of γ-Diamines, β-Amino Ketones, and Derivatives with Two and Three Chiral Centers

Article abstract of DOI:10.1021/jo00161a022

1,3-Diimes 1 are easily reduced with Na/i-PrOH to afford unsymmetrical N-substituted γ-diamines 8 in nearly quantitative yields.Since three chiral centers are generated, compounds 8 are isolated as a mixture of diastereoisomers which are easily separated.