Tetrahedron Letters p. 4793 - 4796 (1982)
Update date:2022-08-02
Topics:
Himmelsbach, Frank
Pfleiderer, Wolfgang
A new phosphorylating agent, bis-(p-nitrophenylethyl)phosphoromonochloridate, has been prepared and used for 3'- and/or 5'-phosphorylations of nucleosides.The resulting bis-(p-nitrophenylethyl)phosphotriesters are versatile synthons in oligonucleotide syntheses leading finally to 3'- and/or 5'-terminated oligonucleotides in excellent yields.
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