Journal of Organic Chemistry p. 1813 - 1819 (1983)
Update date:2022-07-29
Topics:
Leland, David L.
Kotick, Michael P.
A lipophilic 4-phenylbutyl group was selectively incorporated into the 7α- or 7β-position of the morphine nucleus by use of 6,7-oxymethylene (oxetane) intermediates. 7,7-Bis<(tosyloxy)methyl>dihydroisocodeine (2) with dilute NaOH gave 6β,7β-(oxymethylene)
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Doi:10.1021/ja01251a003
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