CYANOGEN CHLORIDE N-OXIDE CYCLOADDITIONS. A SIMPLE, SHORT ROUTE TO AT-125.

DOI: 10.1016/S0040-4039(00)85654-3

Source and publish data:

Tetrahedron Letters p. 4563 - 4566 (1982)

Update date:2022-07-30

Topics:

Authors:

Wade, P. A.

Pillay, M. K.

Singh, S. M.

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Article abstract of DOI:10.1016/S0040-4039(00)85654-3

Addition of AgNO3 to dichloroformaldoxime in the presence of alkenes provides an efficient procedure for the preparation of 3-chloroisoxazolines including AT-125.

Full text of DOI:10.1016/S0040-4039(00)85654-3

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Product name:(4S,5S)-3-Chloro-5-methyl-4-phenyl-4,5-dihydro-isoxazole

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