Studies on analgesic oligopeptides. II. Structure-activity relationship among thirty analogs of a cyclic dipeptide, cyclo(-Tyr-Arg-)

DOI: 10.1248/cpb.30.4435

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4435 - 4443 (1982)

Update date:2022-07-30

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Authors:

Sasaki Sasaki

Akutsu Akutsu

Matsui Matsui

Suzuki Suzuki

Sakurada

Sato Sato

Kisara Kisara

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Article abstract of DOI:10.1248/cpb.30.4435

Thirty diketopiperazines were synthesized as analogs of cyclo(-Tyr-Arg-). The analgesic activities of these analogs were evaluated after intracerebral administration in mice. In the cyclo(-X-Arg-) series of analogs, cyclo[-Tyr(Et)-Arg-] showed the most po

Full text of DOI:10.1248/cpb.30.4435

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