Photoinitiated bromination of 3-methylceph-3-em 1S-oxide esters. A convenient synthesis of 3-substituted cephalosporins from penicillins

Article abstract of DOI:10.1016/S0040-4020(01)91829-0

Photoinitiated bromination of 3-methyl-ceph-3-em 1S-oxide esters 2, readily obtained from penicillins, gave the corresponding 3-bromomethyl derivatives 5. The 3-bromomethyl 1S-oxides 5b and 5c were converted into the salts 12 and 13 of the 3-methylthiomet