Ortho Substituent Effects in Amide Hydrolysis of Maleanilic Acid Derivatives. Stabilization of Positive Charge Developed in the Transition State

DOI: 10.1021/jo00163a002

Source and publish data:

Journal of Organic Chemistry p. 2453 - 2456 (1983)

Update date:2022-08-03

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Authors:

Suh, Junghun

Kim, Mahn Joo

Kim, Chong Bok

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Article abstract of DOI:10.1021/jo00163a002

The effects of ortho substituents on the rate of the hydrolysis of maleanilic acid derivatives have been studied.The rate is enhanced up to 55 times by polar substituents, while it is retarded greatly by nonpolar substituents.The acceleration by the polar

Full text of DOI:10.1021/jo00163a002

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