Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner

DOI: 10.1021/jm049021k

Source and publish data:

Journal of Medicinal Chemistry p. 4962 - 4971 (2005)

Update date:2022-08-03

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Authors:

Zhang, Shijun

Zhen, Juan

Reith, Maarten E. A.

Dutta, Aloke K.

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Article abstract of DOI:10.1021/jm049021k

In our structure-activity relationship study on 3,6-disubstituted pyran derivatives, we have carried out asymmetric synthesis and biological characterization of trisubstituted (2S,4R,5R)-2-benzhydryl-5- benzylaminotetrahydropyran-4-ol and (3S,4R,6S)-6-ben

Full text of DOI:10.1021/jm049021k

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