Journal of Medicinal Chemistry p. 5104 - 5107 (2005)
Update date:2022-08-04
Topics:
Guo, Zhiqiang
Tellew, John E.
Gross, Raymond S.
Dyck, Brian
Grey, Jonathan
Haddach, Mustapha
Kiankarimi, Mehrak
Lanier, Marion
Li, Bin-Feng
Luo, Zhiyong
McCarthy, James R.
Moorjani, Manisha
Saunders, John
Sullivan, Robert
Zhang, Xiaohu
Zamani-Kord, Said
Grigoriadis, Dimitri E.
Crowe, Paul D.
Chen, Ta Kung
Williams, John P.
The synthesis and SAR studies of tricyclic imidazo[4,5-b]pyridin-2-ones as human corticotropin-releasing factor receptor (CRF1) antagonists are discussed herein. Compound 16g was identified as a functional antagonist that inhibited CRF-stimulat
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Doi:10.1021/acs.joc.9b00441
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