Structure-activity studies of 3′-4′-dichloro-meperidine analogues at dopamine and serotonin transporters

DOI: 10.1016/j.bmc.2005.05.025

Source and publish data:

Bioorganic and Medicinal Chemistry p. 5623 - 5634 (2005)

Update date:2022-08-05

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Authors:

Rhoden, Jill B.

Bouvet, Maud

Izenwasser, Sari

Wade, Dean

Lomenzo, Stacey A.

Trudell, Mark L.

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Article abstract of DOI:10.1016/j.bmc.2005.05.025

The structure-activity relationships of 3′,4′-dichloro- meperidine were investigated at dopamine (DAT) and serotonin transporters (SERT). Large ester substituents and lipophilic groups at the 4-position favored molecular recognition at the SERT. The benzy

Full text of DOI:10.1016/j.bmc.2005.05.025

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