Synthetic studies on carbapenem antibiotics from penicillins. II. Regio- and stereoselective aldol reaction of a chiral azetidinone: A synthesis of optically active 6-epicarpetimycins

Article abstract of DOI:10.1016/S0040-4039(01)91123-2

Aldol and alkylation reactions of the chiral 4-allylazetidinone 1 gave 3,4-trans-azetidinones as major products, in which 10 was converted in several steps to the optically active 6-epicarpetimycins 2.