Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents

DOI: 10.1021/jm00148a006

Source and publish data:

Journal of Medicinal Chemistry p. 1405 - 1413 (1985)

Update date:2022-08-05

Topics:

Authors:

Sircar, Ila

Duell, Bradley L.

Bobowski, George

Bristol, James A.

Evans, Dale B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00148a006

A series of 4,5-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we

Full text of DOI:10.1021/jm00148a006

Products guided by the article

Product name:4-(1H-1,2,4-triazol-1-yl)-γ-oxobenzenebutanoic acid

Cas No:86798-70-1

R&D Labs maybe for 86798-70-1

Shandong Zhongcheng Barium Salt Co., Ltd

Contact:+86-15725732638

Address:No.29 baoxi road, hi-tech zone, zibo, shandong
Xiamen Huasing Chemicals Co.Ltd.

Contact:0086-592-6228397

Address:NO.24, Xinglin North 2nd Road,Jimei district
Anhui Sunsing Chemicals Co.,Ltd

website:http://www.sunsingchem.com

Contact:0086-566-2023179

Address:Jin An industry park, Chizhou economic technical development zone, Anhui
DU-HOPE INTERNATIONAL GROUP

Contact:+86-25-52346955

Address:199,JIANYE ROAD,NANJING,CHINA
JenKem Technology Co., Ltd.

Contact:86-10-62983737; +86-10-51287608

Address:4/F Building C, 2 Shangdi Xinxi Road

Relevant to this article

Synthesis of 2,2'-bipyridyl-type compounds via the Suzuki-Miyaura cross-coupling reaction

Doi:10.1002/jhet.5570440213
(2007)
Nickel(II) and palladium(II) complexes with an alkane-bridged macrocyclic ligand: Synthesis, characterization, and polymerization tests

Doi:10.1021/om0503904
(2005)
A trithiol protio-ligand and its fixation to the periphery of a carbosilane dendrimer as scaffolds for polynuclear rhodium and iridium complexes and metallodendrimers

Doi:10.1021/om0504957
(2005)
Design, docking studies and molecular iodine catalyzed synthesis of benzo[a]xanthen-one derivatives as hyaluronidase inhibitors

Doi:10.1007/s00044-016-1655-2
(2016)
Novel method for preparation of highly substituted 6-arylpurines by reactions of 6-alkynylpurines with zirconacyclopentadienes

Doi:10.1135/cccc20050339
(2005)
Development of building blocks for the synthesis of N-heterocyclic carbene ligands

Doi:10.1021/ol0516521
(2005)

Article Doi