Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents

DOI: 10.1021/jm00148a006

Source and publish data:

Journal of Medicinal Chemistry p. 1405 - 1413 (1985)

Update date:2022-08-05

Topics:

Authors:

Sircar, Ila

Duell, Bradley L.

Bobowski, George

Bristol, James A.

Evans, Dale B.

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Article abstract of DOI:10.1021/jm00148a006

A series of 4,5-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we

Full text of DOI:10.1021/jm00148a006

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