Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents

DOI: 10.1021/jm00148a006

Source and publish data:

Journal of Medicinal Chemistry p. 1405 - 1413 (1985)

Update date:2022-08-05

Topics:

Authors:

Sircar, Ila

Duell, Bradley L.

Bobowski, George

Bristol, James A.

Evans, Dale B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00148a006

A series of 4,5-dihydro-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we

Full text of DOI:10.1021/jm00148a006

Products guided by the article

Product name:4-(1H-1,2,4-triazol-1-yl)-γ-oxobenzenebutanoic acid

Cas No:86798-70-1

R&D Labs maybe for 86798-70-1

Tangshan Moneide Trading Co., Ltd.

Contact:+86-315-8309571

Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Anhui Sunsing Chemicals Co.,Ltd

website:http://www.sunsingchem.com

Contact:0086-566-2023179

Address:Jin An industry park, Chizhou economic technical development zone, Anhui
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
Shanghai ZaiQi Bio-Tech Co., Ltd.,

Contact:+86-21-5482 4098

Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Changzhou Kingyo Chemical Corporation Ltd.

website:http://www.kingyochem.com

Contact:+86-519-85105717

Address:19# Wuqing North Road, Changzhou , Jiangsu, China

Relevant to this article

Synthesis of 2,2'-bipyridyl-type compounds via the Suzuki-Miyaura cross-coupling reaction

Doi:10.1002/jhet.5570440213
(2007)
Nickel(II) and palladium(II) complexes with an alkane-bridged macrocyclic ligand: Synthesis, characterization, and polymerization tests

Doi:10.1021/om0503904
(2005)
A trithiol protio-ligand and its fixation to the periphery of a carbosilane dendrimer as scaffolds for polynuclear rhodium and iridium complexes and metallodendrimers

Doi:10.1021/om0504957
(2005)
Design, docking studies and molecular iodine catalyzed synthesis of benzo[a]xanthen-one derivatives as hyaluronidase inhibitors

Doi:10.1007/s00044-016-1655-2
(2016)
Novel method for preparation of highly substituted 6-arylpurines by reactions of 6-alkynylpurines with zirconacyclopentadienes

Doi:10.1135/cccc20050339
(2005)
Development of building blocks for the synthesis of N-heterocyclic carbene ligands

Doi:10.1021/ol0516521
(2005)

Article Doi