New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases

Article abstract of DOI:10.1016/j.ejmech.2018.03.067

The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and N⁶-position, respectively, is reported. The compounds were tested with radioligand binding studies showing, in some cases, a low