Syntheses and Reactions of Pyridazine Derivatives, XVIII: Synthesis of Novel Halogen Containing 5-Aroylpyridazine-4-carboxylic Acids and Phenyl 4-Pyridazinyl Ketones

Article abstract of DOI:10.1002/ardp.19833160607

The ketocarboxylic acids 4c-h were prepared by Minisci-reaction of ethyl pyridazine-4-carboxylate, followed by alkaline hydrolysis of the resulting esters 2.Compounds 4 are also obtained by homolytic aroylation of pyridazine-4-carboxylic acid.The hitherto unknown aryl 4-pyridazinyl ketones 5c, d, f, g, h were prepared by decarboxylation of carboxylic acids 4.