Preparation of the MacMillan imidazolidinones

DOI: 10.1016/j.tet.2011.04.009

Source and publish data:

Tetrahedron p. 4263 - 4267 (2011)

Update date:2022-08-04

Topics:

Authors:

Samulis, Leopold

Tomkinson, Nicholas C.O.

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Article abstract of DOI:10.1016/j.tet.2011.04.009

A general method for the preparation of the MacMillan imidazolidinones is described. Treatment of an α-amino amide with a carbonyl compound in refluxing chloroform in the presence of Yb(OTf)₃ (1 mol %) provides convenient access to the corresponding imidazolidinones.

Full text of DOI:10.1016/j.tet.2011.04.009

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