Efficient synthesis of [3H]-sanglifehrin A via selective oxidation/reduction of alcohols at C31 and C35

DOI: 10.1021/jo051112h

Source and publish data:

Journal of Organic Chemistry p. 9588 - 9590 (2005)

Update date:2022-08-03

Topics:

Authors:

Wagner, Juergen

Andres, Hendrik

Rohrbach, Stefan

Wagner, Dieter

Oberer, Lukas

France, Julien

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Article abstract of DOI:10.1021/jo051112h

Sanglifehrin A is a novel complex natural product showing strong immunosuppressive activity and remarkably high affinity for cyclophilin A. To assess its pharmacokinetic properties in vivo, an efficient synthetic route was developed to introduce a tritium

Full text of DOI:10.1021/jo051112h

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