A stereospecific synthesis of both enantiomers of 2-(1'-amino-2'-methylpropyl)imidazole, a key synthon in the synthesis of SB 203386; a potent protease inhibitor

Article abstract of DOI:10.1016/S0040-4039(97)00070-1

Two methods for the asymmetric synthesis of both enantiomers of 2-(1'-amino-2'-methylpropyl)imidazole (2) have been developed by adding nucleophilic organometallics to nonracemic 2-oxazolidinones employing 2-phenylglycinol as the source of chirality. Exce