Synlett p. 2670 - 2672 (2005)
Update date:2022-08-03
Topics: Characterization Optimization Purification Introduction of chirality Scale-up Functional Groups Spacer Length Chiral Centers
Arai, Takayoshi
Mizukami, Tomoe
Yokoyama, Naota
Nakazato, Daisuke
Yanagisawa, Akira
A chiral nitrogen-tethered bis (imidazoline) ligand (Nb-imidazoline) was newly designed and synthesized in a divergent strategy. Thus, a single coupling reaction of primary amine with two molecules of chloromethylated imidazoline provided the Nb-imidazoline. The copper(II) triflate complex of Nb-imidazoline catalyzed a trans-selective cyclopropanation of styrene with ethyl diazoacetate to give the adduct in high chemical yield with good enantiomeric excess up to 83%. Georg Thieme Verlag Stuttgart.
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