6-AZABICYCLOOCTANE DERIVATIVES. SYNTHESIS OF THE 8,12-METHANOAZEPINOISOQUINOLINE SYSTEM.

DOI: 10.1016/S0040-4020(01)88678-6

Source and publish data:

Tetrahedron p. 1723 - 1728 (1983)

Update date:2022-08-05

Topics:

Authors:

Bonjoch, Josep

Mestre, Esther

Cortes, Roser

Granados, Ricardo

Bosch, Joan

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Article abstract of DOI:10.1016/S0040-4020(01)88678-6

The synthesis of the 8,12-methanoazepino<2,1-α>isoquinoline system 1 by Bischler-Napieralski cyclization of an appropriate 6-phenethyl-6-azabicyclo<3.2.1>octan-7-one derivative 2 is described.Lactam 2 was prepared by three alternative procedures: (a) dire

Full text of DOI:10.1016/S0040-4020(01)88678-6

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