Synthesis and evaluation of 3-halocyclophosphamides and analogous compounds as novel anticancer 'pro-prodrugs'

DOI: 10.1002/jps.2600720622

Source and publish data:

Journal of Pharmaceutical Sciences p. 687 - 691 (1983)

Update date:2022-07-30

Topics:

Authors:

Zon Zon

Ludeman Ludeman

Ozkan Ozkan

Chandrasegaran

Hammer Hammer

Dickerson

Mizuta Mizuta

Egan Egan

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Article abstract of DOI:10.1002/jps.2600720622

3-Fluoro-, 3-chloro-, and 3-bromocyclophosphamide were prepared from the reaction of trifluoromethylhypofluorite, sodium hypochlorite, and bromine with the anticancer drug cyclophosphamide. Treatment of cis-, and trans-4-phenylcyclophosphamide and 5,6-ben

Full text of DOI:10.1002/jps.2600720622

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