Tetrahedron Letters p. 2927 - 2930 (1983)
Update date:2022-08-03
Topics:
Raucher, Stanley
Lawrence, Ross F.
N-carbomethoxy-5-ethyl-1,2-dihydropyridine (1) may be prepared by the bromination of N-carbomethoxy-3-ethyl-1,2,5,6-tetrahydropyridine (10), and subsequvent double dehydrobromination with EtAlCl2/HMPA; this diene undergoes Diels-Alder reaction with dimethyl methylenemalonate (2) to give the isoquinuclidine (3), an intermediate in our planned approach to catharanthine.
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Doi:10.1007/BF00568269
()Doi:10.1016/S0040-4039(00)88321-5
(1983)Doi:10.1002/recl.19831020505
(1983)Doi:10.1021/ol052462t
(2005)Doi:10.1021/acs.orglett.7b01726
(2017)Doi:10.1039/jr9450000660
(1945)
