STEREOSELECTIVE ACYCLIC KETONE REDUCTION. SYNTHESIS OF THE SYNTHONS HAVING THREE CONSECUTIVE CHIRAL CENTERS

Article abstract of DOI:10.1016/0040-4020(84)80005-8

Four possible diastereomers of a functionalized 1,3-dimethyl-2-hydroxy unit were synthesized based on the stereoselective reduction of various acyclic ketones (i.e. reduction of β-keto ester, β-hydroxy ketone, α-hydroxy ketone, and α-silyloxy ketone) and