Engineering D-amino acid containing novel protease inhibitors using catalytic site architecture

Article abstract of DOI:10.1016/j.bmc.2005.08.019

The mechanism of proteolysis by serine proteases is a reasonably well-understood process. Typically, a histidine residue acting as a general base deprotonates the catalytic serine residue and the hydrolytic water molecule. We disclose here, the use of an