Bioorganic and Medicinal Chemistry Letters p. 5390 - 5395 (2007)
Update date:2022-08-05
Topics:
Coleman, Paul J.
Schreier, John D.
Cox, Christopher D.
Fraley, Mark E.
Garbaccio, Robert M.
Buser, Carolyn A.
Walsh, Eileen S.
Hamilton, Kelly
Lobell, Robert B.
Rickert, Keith
Tao, Weikang
Diehl, Ronald E.
South, Vicki J.
Davide, Joseph P.
Kohl, Nancy E.
Yan, Youwei
Kuo, Lawrence
Prueksaritanont, Thomayant
Li, Chunze
Mahan, Elizabeth A.
Fernandez-Metzler, Carmen
Salata, Joseph J.
Hartman, George D.
3,5-Diaryl-4,5-dihydropyrazoles were discovered to be potent KSP inhibitors with excellent in vivo potency. These enzyme inhibitors possess desirable physical properties that can be readily modified by incorporation of a weakly basic amine. Careful adjust
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