Bioorganic and Medicinal Chemistry Letters p. 996 - 999 (2012)
Update date:2022-08-02
Topics:
Orain, David
Ofner, Silvio
Koller, Manuel
Carcache, David A.
Froestl, Wolfgang
Allgeier, Hans
Rasetti, Vittorio
Nozulak, Joachim
Mattes, Henri
Soldermann, Nicolas
Floersheim, Philipp
Desrayaud, Sandrine
Kallen, Joerg
Lingenhoehl, Kurt
Urwyler, Stephan
A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED50 of 5.5 mg/kg in an animal model of anticonvulsant activity after oral dosage.
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Doi:10.1016/S0008-6215(00)85528-7
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