Synthesis of 3-Hydroxy-2- and 4-pyridone Nucleosides as Potential Antitumor Agents

Article abstract of DOI:10.1021/jm00368a010

The ribo- and arabinofuranosyl nucleosides of antitumor active 2- and 4-pyridones 1a and 2a were prepared by direct condensation of the silylated bases with either 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (4a) or 2,3,5-tri-O-benzyl-1-p-nitrobenzoyl-D