Bioorganic and Medicinal Chemistry Letters p. 854 - 858 (2006)
Update date:2022-08-05
Topics:
Sabatucci, Joseph P.
Ashwell, Mark A.
Trybulski, Eugene
O'Donnell, Mary-Margaret
Moore, William J.
Harnish, Douglas C.
Chadwick, Christopher C.
The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.
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