Tetrahedron p. 2803 - 2806 (1983)
Update date:2022-08-03
Topics:
Bellamy, F. D.
Chazan, J. B.
Ou, K.
Three compounds, 2a, 2b, and 2c have been synthesized by an analogy with glaziovine 1 which has been claimed to have anxiolytic properties similar to diazepam.The intermediates indanones 5 have been obtained according to conventional (for 5a) or less conventional procedure (5b) and then converted to the corresponding indanones 11.Michael addition of methylbenzylamine followed by a one-carbon homologation of the ketone gave an aldehyde suitable for Robinson annulation leading to the spiro compounds 2.DDQ oxidation gave 3.No anxiolytic activity was found from the pharmacological data.
View MoreSuzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Contact:86-791-86629460
Address:1-6F, 118 Xinzhou road, Nanchang, Jiangxi, China
ChangZhou XiaQing Chemical Co., Ltd.
Contact:+86-519-88721665
Address:3# Hengluo Road, Henglin Town, Changzhou City, Jiangsu Province，China
nanjing bam biomedical technology co.，ltd
Contact:86-025-58912721
Address:Kai Tuo Road NO.8,Jiangning District,Nanjing,jiangsu Province,china
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Doi:10.1002/anie.200500751
(2006)Doi:10.1021/ja00315a049
(1984)Doi:10.1016/j.bmcl.2007.10.090
(2008)Doi:10.1021/ol0528991
(2006)Doi:10.1039/c8ob00532j
(2018)Doi:10.1016/j.jorganchem.2005.10.034
(2006)
