Bioorganic and Medicinal Chemistry Letters p. 1277 - 1281 (2006)
Update date:2022-07-31
Topics:
Wiles, Jason A.
Song, Yongsheng
Wang, Qiuping
Lucien, Edlaine
Hashimoto, Akihiro
Cheng, Jijun
Marlor, Christopher W.
Ou, Yangsi
Podos, Steven D.
Thanassi, Jane A.
Thoma, Christy L.
Deshpande, Milind
Pucci, Michael J.
Bradbury, Barton J.
We synthesized a diverse series of 9H-isothiazolo[5,4-b]quinoline-3,4- diones containing heteroaromatic groups at the 7-position via palladium-catalyzed cross-coupling. Many of these compounds demonstrated potent antistaphylococcal activity (MICs ≤2 μg/mL) against a multi-drug-resistant strain (ATCC 700699) and low cytotoxic activity (CC50 > 100 μM) against the human cell line Hep2 (laryngeal carcinoma).
View MoreSPRING CHEMICAL INDUSTRY CO.,LTD
Contact:86-187-66672125
Address:linchi industry park.zouping
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Xi'an North Information Industry Co., Ltd. Weilv Chemical Department
Contact:+86-29-88156413
Address:Jixiang Road 99 Xi'an Shaanxi Province
LIAONING DMSO CHEMICALS CO.,LTD.
website:http://www.chinadmso.com
Contact:+86-427-6503033
Address:FLOOR 16, BLOCK A, FINANCIAL SQUARE, XINGLONGTAI DISTRICT, PANJIN CITY, LIAONING P.R. CHINA
Contact:86-551-63540590
Address:No 1388 Furong Rd., Hefei, Anhui, China
Doi:10.1021/ja057747f
(2006)Doi:10.1007/BF01134185
(1983)Doi:10.1016/j.jorganchem.2005.10.049
(2006)Doi:10.1021/jo0523363
(2006)Doi:10.1016/j.tetlet.2010.10.163
(2011)Doi:10.1016/j.bmcl.2005.06.044
(2005)