interactions between the dendritic molecules and structured RNA
molecules.
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Conclusion
In conclusion, tri(ethylene glycol) derived dendritic compounds
with various amine end groups were synthesized and their
properties of binding and assembly with RNA were assessed
using the Candida ribozyme as a model RNA molecule. The
amine terminating dendrimers bind strongly to the ribozyme
and efficiently inhibit the activity of the ribozyme, as shown by
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Acknowledgements
We are grateful to Bao Penghui and Chen Zhiqiang for ribozyme
preparation, Dr. Liu Minghua for CD analysis. Dr Laurence
Charles thanks Spectropoˆle, the Analytical Facility of Aix-
Marseille Universities, for technical support in this study by allow-
ing special access to the instruments. Financial support from the
Ministry of Science and Technology of China (N◦2003CB114400,
2003CB514102, 2003AA2Z3506), National Science Foundation
of China (N◦20572081, 30330170, 30170213), Wuhan University,
Cheung Kong Scholar Foundation, AFM and CNRS is gratefully
acknowledged.
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