
Journal of the Chemical Society. Perkin transactions I p. 1925 - 1928 (1983)
Update date:2022-08-03
Topics:
Bachi, Mario D.
Klein, Joseph
A method has been developed for the preparation of dihydroxydihydroazeto<1,2-a>quinoline-1,4(2H)-diones (1).The synthesis involved, as a key step, the completion of the polycyclic β-lactam system by a modified Bischler-Napieralski reaction.It was illustrated by the synthesis of (+/-)-7,8-dihydroxy-3,3-dimethyl-2-phenoxyacetamido-2a,3-dihydroazeto<1,2-a>quinoline-1,4(2H)-dione (20), which is structurally related to the carbacephalosporin antibiotics.
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