Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors

DOI: 10.1016/j.bmcl.2007.03.078

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3463 - 3467 (2007)

Update date:2022-08-04

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Authors:

Alam, Mahbub

Beevers, Rebekah E.

Ceska, Tom

Davenport, Richard J.

Dickson, Karen M.

Fortunato, Mara

Gowers, Lewis

Haughan, Alan F.

James, Lynwen A.

Jones, Mark W.

Kinsella, Natasha

Lowe, Christopher

Meissner, Johannes W.G.

Nicolas, Anne-Lise

Perry, Benjamin G.

Phillips, David J.

Pitt, William R.

Platt, Adam

Ratcliffe, Andrew J.

Sharpe, Andrew

Tait, Laura J.

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Article abstract of DOI:10.1016/j.bmcl.2007.03.078

The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.

Full text of DOI:10.1016/j.bmcl.2007.03.078

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