New Sesquiterpenoids from Clary Sage Oil (Salvia sclarea L.)

Article abstract of DOI:10.1002/hlca.19830660734

Six sesquiterpenoids, (2R,5E)-2,12-epoxycaryophyll-5-ene (1), (2R,5E)-caryophyll-5-en-12-al (2), (2S,5E)-caryophyll-5-en-12-al (3), isospathulenol (4), (1R,5R)-1,5-epoxysalvial-4(14)-ene (5), and salvial-4(14)-en-1-one (6) have been identified for the first time in clary sage oil (Salvia sclarea L.).The structures and absolute configurations of 1-6 are corroborated by partial syntheses and their organoleptic properties are discussed.The compounds 5, 6 and mintsulfide (14) possess the rare C-skeleton C, for which the semisystematic name 'salvialane' is proposed.The sesquiterpenoids 1-5 are new.