Bioorganic and Medicinal Chemistry Letters p. 2037 - 2041 (2006)
Update date:2022-07-29
Topics:
Young, Wendy B.
Mordenti, Joyce
Torkelson, Steven
Shrader, William D.
Kolesnikov, Aleksandr
Rai, Roopa
Liu, Liang
Hu, Huiyong
Leahy, Ellen M.
Green, Michael J.
Sprengeler, Paul A.
Katz, Bradley A.
Yu, Christine
Janc, James W.
Elrod, Kyle C.
Marzec, Ulla M.
Hanson, Stephen R.
Highly selective and potent factor VIIa-tissue factor (fVIIa · TF) complex inhibitors were generated through structure-based design. The pharmacokinetic properties of an optimized analog (9) were characterized in several preclinical species, demonstrating
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