The reactivity of related 6-amino- and 5,6-diaminouracils derived from 2-amino-5-(phenoxymethyl)-2-oxazoline: Efficient access to bicyclic pyrimidine derivatives

Article abstract of DOI:10.1055/s-2007-983748

8-(Dimethylamino)-3-(2-hydroxy-3-phenoxypropyl)-xanthine has been obtained from 6-amino-1-(2-hydroxy-3-phenoxypropyl)uracil by an azodicarboxylate Michael-type addition involving a reactive diene. 6-Amino-1-(2-hydroxy-3- phenoxypropyl)uracil was easily pr