Synthesis of (N-acetyl-1-O-acylmuramoyl)-L-alanyl-D-isoglutamines, and their immunoadjuvant activities.

Article abstract of DOI:10.1016/0008-6215(83)88381-5

1-O-Acyl derivatives of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP) have been synthesized from 2-acetamido-1-O-benzoyl-4,6-O-isopropylidene-3-O-[D-1-(methoxycarbonyl) ethyl]-alpha-D-glucopyranose. Their immunoadjuvant activities were examined in guinea