Amino acids and peptides. IX. Synthesis of cysteine-containing peptide fragments related to human hepatic metallothionein II (hMT II) and determination of their heavy metal-binding properties

DOI: 10.1248/cpb.31.3094

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3094 - 3103 (1983)

Update date:2022-08-05

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Authors:

Ohta Ohta

Okada Okada

Tanaka Tanaka

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Article abstract of DOI:10.1248/cpb.31.3094

Eight kinds of cysteine-containing peptides related to human hepatic metallothionein were synthesized by conventional methods. The metal-binding properties of these peptides with Zn²⁺ and Cd²⁺ were indicated by an increase of ultraviolet absorbance resulting from mercaptide formation. The Cd-binding activities of various peptides obtained here were assessed by measuring the increase in absorbance of mercaptide at 250 mm as a function of the concentration of Cd. The binding abilities of the peptides with Cd differed substantially.

Full text of DOI:10.1248/cpb.31.3094

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