Tetrahedron Letters p. 5085 - 5088 (1983)
Update date:2022-08-05
Topics:
Giffard, Michel
Cousseau, Jack
Action of primary amines on vic-halo-thiocyanato alkenes R1-C(-SCN)=CX-R%&2 affords 2-amino 1,3-thiazoles, the cyclisation taking place with migration of the sulphur atom on the C=C bond; thus 2-cyclohexylamino 5-propyl 1,3-thiazole is obtained
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