Syntheses of 5-substituted oxazole-4-carboxylic acid derivatives with inhibitory activity on blood platelet aggregation

DOI: 10.1248/cpb.31.4417

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4417 - 4424 (1983)

Update date:2022-07-30

Topics: Inhibitory activity Syntheses Experimental terms Chemical terms

Authors:

Ozaki Ozaki

Maeda Maeda

Iwasaki Iwasaki

Matsumoto

Odawara Odawara

Sasaki Sasaki

Morita Morita

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Article abstract of DOI:10.1248/cpb.31.4417

Methyl 5-substituted oxazole-4-carboxylates were synthesized by the reaction of methyl α-isocyanoacetate with acylating reagents in the presence of bases. The oxazole methyl esters were converted into the carboxylic acids and the carboxamides. Then, N-alk

Full text of DOI:10.1248/cpb.31.4417

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