Tetrahedron Letters p. 281 - 284 (1984)
Update date:2022-09-26
Topics:
Frater, G.
Mueller, U.
Schoepfer, U.
3-Cyclohexenecarboxylic acid (2) has been functionalized to the protected amino acid 5 in a novel reaction sequence, the crucial step being the acid catalysed cyclization of the γ,δ-unsaturated isocyanate 3 to the bicyclic lactam 4. 5 was converted into gabaculine hydrochloride (l <*> HCl).
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(2006)Doi:10.1002/oms.1210190106
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(1984)Doi:10.1021/om060249a
(2006)Doi:10.1016/0008-6215(87)80044-7
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