Journal of Fluorine Chemistry p. 557 - 572 (1983)
Update date:2022-08-03
Topics: Pharmacological Testing
Middleton, W. J.
Bingham, E. M.
Smith, D. H.
Benzodiazepines that bear a fluorine substituent in the metabolically active C-3 position were prepared by the reaction of diethylaminosulfur trifluoride (DAST) with the corresponding 3-hydroxybenzodiazepines.These products are surprisingly stable to hydrolysis and possess potent antianxiety and muscle-relaxing properties.
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