3-FLUOROBENZODIAZEPINES

DOI: 10.1016/S0022-1139(00)85140-4

Source and publish data:

Journal of Fluorine Chemistry p. 557 - 572 (1983)

Update date:2022-08-03

Topics: Pharmacological Testing

Authors:

Middleton, W. J.

Bingham, E. M.

Smith, D. H.

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Article abstract of DOI:10.1016/S0022-1139(00)85140-4

Benzodiazepines that bear a fluorine substituent in the metabolically active C-3 position were prepared by the reaction of diethylaminosulfur trifluoride (DAST) with the corresponding 3-hydroxybenzodiazepines.These products are surprisingly stable to hydrolysis and possess potent antianxiety and muscle-relaxing properties.

Full text of DOI:10.1016/S0022-1139(00)85140-4

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