Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated Aldehydes

Article abstract of DOI:10.1021/acs.oprd.8b00379

Electrolysis flow reactors based on the filter-press architecture of redox flow batteries have proven to be effective and scalable toward the production of commercially relevant, pharmaceutical quantities of anilines (>500 kg/year) from halogen-, hydroxyl-, and carbonyl-substituted nitroarenes. Turbulent flow through the carbon felts on which the catalysts were supported facilitated scaling toward production levels because it conferred on the reactors scale-independent, plug flow-like residence time distributions and high mass transfer coefficients. Equipping the cells with microreference electrodes made it possible to transfer reaction conditions first developed in batch systems to the continuous flow reactors. The catalysts prepared by incipient wetness impregnation of metal salts into lightly oxidized carbon felt supports were readily generalizable.

Full text of DOI:10.1021/acs.oprd.8b00379

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Full Paper
Development and Scale-up of Continuous Electrocatalytic Hydrogenation
of Functionalized Nitroarenes, Nitriles and Unsaturated Aldehydes
Jonathan D Egbert, Edwin C. Thomsen, Stacy A. O'Neill-Slawecki, Douglas M
Mans, David C. Leitch, Lee J. Edwards, Charles E Wade, and Robert S. Weber
Org. Process Res. Dev., Just Accepted Manuscript • DOI: 10.1021/acs.oprd.8b00379 • Publication Date (Web): 08 Jul 2019
Downloaded from pubs.acs.org on July 12, 2019
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Organic Process Research & Development
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