Bioorganic Chemistry p. 129 - 135 (2003)
Update date:2022-09-26
Topics:
Shiino, Mitsuhiro
Watanabe, Yumi
Umezawa, Kazuo
Several novel N-substituted N-nitrosohydroxylamines were synthesized. They all inhibited mushroom tyrosinase, but the type of inhibition was different depending on the substituent. Some N-(mono- or dihydroxybenzyl)-N-nitrosohydroxylamines exhibited uncompetitive inhibition with respect to L-dopa. Among them, compound 6 was also a competitive inhibitor with respect to oxygen. This observation suggests that another interaction by the meta- or para-hydroxyl group might stabilize the binding of the inhibitor to the enzyme through the oxygen binding site.
View Morewebsite:http://www.antaibio.com
Contact:86-21-60939051,60939771
Address:1518#,ZHANGYANG ROAD
Melone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
Chongqing Changfeng Chemical Co., Ltd.
website:http://www.changfengchem.com
Contact:+86-23-67896333
Address:30th Floor, Longhu Ziduxingzuo Building A, 1st Branch,YuSong Rd., Yubei District, Chongqing, China
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)
Contact:86-532-67773200; 15689126900
Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
Doi:10.1021/ml500162z
(2014)Doi:10.1021/jm9707129
(1998)Doi:10.1016/j.bmc.2004.06.037
(2004)Doi:10.1021/jo040189n
(2004)Doi:10.1021/jm00357a012
(1983)Doi:10.1016/S0008-6215(00)80681-3
(1981)