Bioorganic and Medicinal Chemistry Letters p. 3564 - 3568 (2006)
Update date:2022-08-03
Topics:
Yan, Lin
Budhu, Richard
Huo, Pei
Lynch, Christopher L.
Hale, Jeffrey J.
Mills, Sander G.
Hajdu, Richard
Keohane, Carol A.
Rosenbach, Mark J.
Milligan, James A.
Shei, Gan-Ju
Chrebet, Gary
Bergstrom, James
Card, Deborah
Mandala, Suzanne M.
A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to
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