Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action

DOI: 10.1021/acs.jmedchem.5b00499

Source and publish data:

Journal of Medicinal Chemistry p. 3767 - 3793 (2015)

Update date:2022-08-15

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Authors:

Mejdrová, Ivana

Chalupská, Dominika

K?gler, Martin

?ála, Michal

Pla?ková, Pavla

Baumlová, Adriana

H?ebabecky, Hubert

Procházková, Eli?ka

Dejmek, Milan

Guillon, Rémi

Strunin, Dmytro

Weber, Jan

Lee, Gary

Birkus, Gabriel

Mertlíková-Kaiserová, Helena

Boura, Evzen

Nencka, Radim

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Article abstract of DOI:10.1021/acs.jmedchem.5b00499

Phosphatidylinositol 4-kinase IIIβ is a cellular lipid kinase pivotal to pathogenesis of various RNA viruses. These viruses hijack the enzyme in order to modify the structure of intracellular membranes and use them for the construction of functional repli

Full text of DOI:10.1021/acs.jmedchem.5b00499

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