Chemical Communications p. 5535 - 5537 (2013)
Update date:2022-08-03
Topics:
Hayashi, Daisuke
Kato, Nobuo
Kuzuyama, Tomohisa
Sato, Yasuo
Ohkanda, Junko
N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 μM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH-lactate dehydrogenase (LDH) is also reported.
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